意思上没有任何区别，区别在于看其做句子的什么成分。
前者做宾语，后者做主语时使用。
其实看me和I的性质就可以看出来了。
一个是被动，即宾语；一个是主动，及主语。
意思都一样，你和我。
口语中区分不明显，但是可以举例区分如下：
“There's no one in here, just you and me !” 这里米有别人，就你和俺！(想象电影里坏人之间小笔毒品交易的情景)
“If the police found out about this, you and I can just pack it up and check in at the front desk in jail.” 如果警察叔叔发现了，你和我就可以直接收拾行李去号子里报到了。（还是坏人……）
可见如果是客观被提到，一般使用you and me。若是作为主语，讨论要做什么，或者是did了什么，就用you and I。
奥运那首歌的歌词“油and米，from one world”，这里请仔细品味一下，就是在客观描述一个状态，所以用me。如果是用“you and I”，那后面就最好改为“are from the same world”，如此就更为流畅顺口一些。（实际上也是不标准的用法）
总结一下 就是You and me 在母语英语的教学中其实是被判断为错误的，比如“you and me are going to the store.”因此很多人在表达中就会“hypercorrection（矫枉过正）”，把一切You and me 都会替换成You and I.
但是最简单的一种判断究竟该用“me”还是“I”的方法就是，在此句子中去掉"You and"
比如，I hate Li Ming. 听起来就没什么问题，但是Me hate Li Ming.就不对了。所以加上You and 以后，就应该是 You and I hate Li Ming.
再比如，Li Ming hates me.就没问题，但是Li Ming hates I.就不正确了。所以加上You and 以后，就应该是Li Ming hates you and me.
This is an example of hypercorrection, which is when native speakers make an accidental error in their zeal to avoid a different error.
In this case, the error that's being avoided is the error of writing "you and me" in subject position, as in the following sentence:
You and me are going to the store.
This is formally incorrect, although it's very common in contemporary spoken English. Because they have been taught that this is incorrect, many people hypercorrect and change "you and me" to "you and I" in all positions. That is, they incorrectly learn the rule about when to use "you and I", and so produce sentences like the following:
You and I are going to the store. [Correct]
He'll come to the store with you and I. [Incorrect]
"You and I" is the subject. "You and me" is the object.
"You and I hate Phil." "Phil hates you and me." "Phil is hated by you and me." All of these are grammatically correct. (No offence to Phil.)
It really winds me up when people hypercorrect because they think that "you and me" is always wrong. "Phil hates you and I." NO! This is worrying.
The best way to work out if you should be using "you and I" or "you and me" is to take away the "you and" and see if the sentence sounds right with just I or me.
"I hate Phil." Sounds good. "Me hate Phil." Sounds like a caveman talking!
"Phil hates me." Sounds good. "Phil hates I." Sounds ridiculous!
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标签：me,区别
